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KMID : 1103920140200040406
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Korean Journal of Hepatology
2014 Volume.20 No. 4 p.406 ~ p.410
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Composite liver tumors: A radiologic-pathologic correlation
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Nayyar Megha
Imagawa David K.
Tirkes Temel
Demirjian Aram N.
Houshyar Roozbeh
Sandrasegaran Kumar
Nangia Chaitali S.
Seery Tara
Bhargava P
Choi Joon-II
Lall Chandana
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Abstract
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Bi-phenotypic neoplasm refers to tumors derived from a common cancer stem cell with unique capability to differentiate histologically into two distinct tumor types. Bi-phenotypic hepatocellular carcinoma-cholangiocarcinoma (HCC-CC), although a rare tumor, is important for clinicians to recognize, since treatment options targeting both elements of the tumor are crucial. Imaging findings of bi-phenotypic HCC-CC are not specific and include features of both HCC and CC. A combination of imaging and immuno-histochemical analysis is usually needed to make the diagnosis.
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KEYWORD
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Hepatoceullular carcinoma, Cholangiocarcinoma, Bi-phenotypic tumors, Computed tomography, Magnetic resonance imaging
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